What was supposed for a while is also now confirmed: Ezio will be back and the game will take place in Rome. Here
Kotaku wrote:"Live and breathe as Ezio, now a legendary master assassin, in his struggle against the Templar order. Lead your own brotherhood of Assassins and strike at the heart of the enemy. Rome,".
"And for the first time, take part in an innovative multiplayer layer allowing you to embody an assassin of your choosing and define their killing style. A never-before-seen online multiplayer experience. Lead your own brotherhood of assassins, as Ezio, and conquer Rome."
The game will be out next Fall... Can't wait !!